PP.36.07

Abstract

Objective: To assess influence of antecedent hypertension on clinical course, cardiac hemodynamics and renal function in patients with acute decompensated heart failure (ADHF). Design and method: We performed a prospective observational study of patients admitted in cardiology ICU with ADHF. A total of 58 patients were enrolled including 40 men (69,0%) and 18 women (31,0%), mean age 64,2 ± 2,3 years. Patients were divided into 2 groups, gr.1 - n = 41 (70,7%) with antecedent hypertension and gr.2 - n = 17 (29,3%) without hypertension. The degree of kidney impairment was assessed by estimation of glomerular filtration rate (eGFR), plasma NT-pro-BNP (ELISA) was measured at the day of admission. Results: There was no significant difference between gr.1 and gr.2 for a frequency of diabetes mellitus 27 (65,9%) vs 10 (58,8%) and atrial fibrillation 15 (36,6%) vs 6 (35,3%), (all p > 0,05). In hypertensive patients renal damage (eGFR < 60 ml/min) was more frequent - 24 (58,5%) vs 5 (29,4%), (p < 0,05). Also patients in gr.1 had higher ejection fraction - 42,7 ± 2,2% vs 38,1 ± 2,1% (p < 0,05), had longer duration of stay in hospital 12,3 ± 2,1 vs 9,1 ± 1,9 days, (p < 0,05). NT-pro-BNP at the 1-st day was significantly higher in gr.1 comparing to gr.2 - 1108 ± 317 vs 837 ± 284 pg/ml, (p < 0,02). Conclusions: In patients admitted in cardiology ICU with ADHF, preexisting hypertension is associated with higher risk of renal impairment, longer duration of stay, and higher NT-pro-BNP.