Abstract
PP-34 - Association of human leukocyte antigen groups with oral mucositis in patients undergoing bone marrow transplantation
Highlights
Oral mucositis (OM) is a frequent early-term complication of hematopoetic stem cell transplantation (HSCT) which influences life quality and is associated with increased morbidity [1, 2]
We identified that some human leukocyte antigen (HLA) alleles correlated with OM severity and duration
One of the patients was transferred to intensive care unit while she had grade 4 OM, so only maximum OM grade of this patient was used in the analyses
Summary
Oral mucositis (OM) is a frequent early-term complication of hematopoetic stem cell transplantation (HSCT) which influences life quality and is associated with increased morbidity [1, 2]. Behçet’s disease, gluten enteropathy, and inflammatory bowel diseases (IBSs) are disorders with mucosa inflammation and have association with certain HLA phenotypes [7,8,9]. The association of OM with HLA phenotypes after HSCT has not been investigated to date. Oral mucositis (OM) after hematopoetic stem cell transplantation (HSCT) may lead to toxicity that impair quality of life. Associations between some diseases and human leukocyte antigen (HLA) groups have been long recognized. A genetic contribution as the association of HLA groups with OM after HSCT, has not been reported to date. We aimed to assess whether an association of HLA phenotype and OM after allogeneic HSCT exists
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