Abstract
Objective: This study designed to compare different obesity indicators as well as determine the best cut of point of obesity indices to incidence of HTN among Iranian population. Design and method: Isfahan Cohort Study was a longitudinal population-based study that was conducted on adults aged 35 years or older, living in urban and rural areas of three districts in central Iran. After 7 years of follow-up, 3283 participants were re-evaluated using a standard protocol similar to the baseline. At both measurements, participants underwent medical interview, physical examination, and fasting blood measurements. Participants (n = 4833) with prevalent hypertension were excluded from the analysis, resulting in a sample size of 2450. Results: The average age of subjects was increased from 47.3 ± 9.4 years in 2001 to 55.4 ± 10.3 years in 2007. After 7 years of follow-up, 542 (22.1%) new cases of HTN were found indicating cumulative incidence (95% CI) of 22.6% (20.3–24.9) in men and 21.6% (19.3–23.9) in women. Of all the anthropometric indices, WHtR was the strongest predictor of HTN in men with almost 1.6 times increase in HTN risk for each SD increase (Table 2). n women, the model that included WHtR better fitted. In the adjusted models, WHpR did not reach significant level in women. IIn men, although all central adiposity indices were independently associated with HTN except for HC, BMI lost its statistically significant association when WC or WHtR were introduced to the models. Conversely in women, WHpRand WHtRshowed a relationship independent to BMI. Height in men significantly decreased hypertension risk in crude models, but not in adjusted models and in women. ROC curve analysis showed the highest discrimination power (AUC) in WHtR for men and women (Table 5). For each anthropometric index the optimal cutoff point is presented maximizing Youden's index for incident HTN and its corresponding sensitivity and specificity in men and women. The highest positive likelihood ratio was observed in the indices with highest AUC. Conclusions: The result of this study revealed that WHtR is the preferred obesity indicator to predict hypertension among Iranian population.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.