PP.25.28] RENALASE PLASMA CONCENTRATION BEFORE AND AFTER RADIOFREQUENCY RENAL DENERVATION IN PATIENTS WITH RESISTANT HYPERTENSION

Abstract

Objective: Renalase is a catecholamine-metabolizing enzyme produced by proximal tubular cells in kidney which is supposed to be involved in blood pressure regulation. The aim of the study was to evaluate plasma renalase concentration before and after radiofrequency renal denervation (RDN) in patients with resistant arterial hypertension. Design and method: 19 patients (10 men, median age 56 (48; 57) years; BMI 30.9 ± 4.4 kg/m2 and eGFR 89 ± 17.7 ml/min/1.73 m2) with resistant hypertension were enrolled in the study. In all patient plasma renalase concentration was measured before and 1, 3, 6 and 12 months after RDN by ELISA method (Cloud-Clone Corp, Houston, USA). Results: A significant decrease of both office systolic and diastolic blood pressure 6 months after RDN was found (192 ± 31 vs. 177 ± 28 mmHg, p = 0.03; 113 ± 23 vs. 99 ± 21 mmHg, p = 0.002, respectively). One and 3 months after RDN plasma renalase concentration decreased significantly (p < 0.05 vs. baseline), with a subsequent return to values comparable with baseline at 6 and 12 months after RDN (NS vs. baseline) (median plasma renalase concentration 22100 vs. 18550 vs. 17600 vs. 20750 vs. 20500 ng/ml, respectively; Friedman analysis of variance p = 0.054). Conclusions: 1. Renal denervation leads to the temporary decrease of plasma renalase concentration in patients with resistant hypertension. 2. Lower plasma renalase concentrations seems to reflect a counteract reaction to blood pressure decline after successful renal denervation.