PP.17.18

Abstract

Objective: Evaluate circadian blood pressure (BP) variation in hypertensive patients and analyze it's association with kidney function. Design and method: Retrospective analysis of 24-h BP monitoring results in 63 hypertensive patients and their clinical, laboratory data was performed. According to nocturnal fall (NF) of BP patients were categorized into following groups. Group A were dippers (NF 10–20%), group B were non-dippers (NF 0–10%), group C were risers (NF < 0%) and group D were extreme dippers (NF > 20%). The relation between circadian BP and renal function was compared with dipping pattern of the patients. Statistical analysis was performed using SPSS 22.0 program. P < 0,05 was considered statistically significant. Results: Results: The 24-h BP monitoring was performed in 63 patients, 26 (41,26%) of them were males, 37 (58,73%) were females. Their mean age was 53,1 ± 18,14 years. Group A consisted of 18 (28,57%) patients, group B of 35 (55,56%) patients, group C of 8 (12,70%) patients and group D of 2 (3,17%) patients. Group D was excluded from further analysis due to low numbers. Mean nocturnal systolic/diastolic BP was 125 ± 19,24/72,61 ± 9,17 mmHg in group A, 135,71 ± 23,22/79,02 ± 14,79 mmHg in group B and 144,25 ± 30,98/77,38 ± 15,7 mmHg in group C, respectively. The differences between the groups in patients mean age and gender were not statistically significant (p = 0,261 and p = 0,286, respectively). We found a statistically significant negative correlation between mean nocturnal systolic BP and glomerular filtration rate (GFR) (r = -0,32; p = 0,011) and positive correlation between mean nocturnal systolic BP and serum creatinine concentration (r = 0,263; p = 0,038). There were no significant differences between groups regarding other values studied, such as cholesterol levels and poteinuria. Conclusions: Abnormal circadian BP pattern was found in more than 70% of patients. We found a statistically significant correlation between circadian BP variation and kidney function: increased nocturnal systolic BP correlated with decreased GFR and increased serum creatinine concentration.