PP.16.17

Abstract

Objective: Many recent studies proposed to use triglyceride/high-density lipoprotein cholesterol (TG/ HDL-C) ratio to predict cardiovascular (CVD) events among European population. In this study we determined the best cut of point of TG/ HDL-C for the first time among Iranian population. Subsequently we compare this cut of point with European cut points as well as metabolic syndrome to predict CVD outcome. Design and method: In this prospective cohort study 6323 Iranian adults over 35 years old, free of cardiovascular diseases and diabetes was followed for 10 years. Metabolic syndrome was defined based on ATPIII criteria. Biochemical and clinical measurements investigated and the best cutoff point for TG/ HDL-C to predict CVD events were determined using receiver operating characteristic curve analysis. The first CVD event was the primary endpoint. Results: According to ROC curve analysis the best cut off points of TG/HDL ratio among Iranian population are 3.76 and 4.42 in women and men, respectively. A hazard ratio of CVD events occurring in individuals at baseline with the best cutoff point of TG/HDL ratio is 1.54 without considering age and sex. This difference slightly increased when adjusted for sex and age (HR = 1.54, 95% CI: 1.33–1.79 vs. HR = 1.58,95% CI: 1.36–1.84), respectively. But in full adjusted model according to sex, age, diabetes, cholesterol level and smoking status HR decreased to HR = 1.46 CI: 1.25–1.71). However full adjusted HR of CVD events based using ATPIII definition is (HR = 1.63 95% CI: 1.37–1.94) which is marginally higher than TG/HDL ratio. Conclusions: An elevated TG/HDL-C ratio appears to be just as effective as the MetS diagnosis in predicting the development of CVD.