PP.14.28] THE STATUS OF CEREBRAL ARTERIES, BLOOD PRESSURE, LEPTIN LEVELS AND POSTPRANDIAL HYPERTRIGLYCERIDEMIA IN PATIENTS WITH CORONARY HEART DISEASE COMBINED WITH HEPATIC STEATOSIS

Abstract

Objective: To estimate the frequency of atherosclerosis of cerebral arteries, blood pressure, leptin levels and postprandial hypertriglyceridemia (PPG) in patients with coronary heart disease (CHD) in combination hepatic steatosis depending on the body mass index. Design and method: The study involved 24 men (group A) with coronary artery disease combined with hepatic steatosis, the control group consisted of 14 patients with coronary artery disease without hepatic steatosis. The study group was divided into 3 subgroups according to BMI (subgroup 1 - patients who are overweight, 2 - obesity 1 degree, 3 - obesity grade 2. Evaluated atherosclerotic changes of the neck vessels, endothelial function, PPG, leptin levels, blood pressure. Results: In the group A point plaques found significantly more often (31%, p = 0,01) when significantly more abuse on the part of endothelial function (47% lower, p = 0,01), than in group B. In patients with grade 2 obesity identified the highest leptin levels (43,6 ± 20,2, p < 0,05), which is 44% higher than in the subgroup with obesity 1 degree (24,4 ± 14,6, p < 0.05) and 63% greater than in the subgroup with overweight. The greatest increase in triglycerides after fat loading test with fixed subgroup 1 (70%) and in the control group (125%). The mean level systolic BP in a group A was higher (145,2 ± 5,8 mmHg) than in group B (129,3 ± 4,4) (p < 0,05). Conclusions: In patients with coronary artery disease combined with hepatic steatosis leptin and PPG have different levels change depending on body weight. Increasing body weight was not associated with further development of atherosclerotic changes in the cerebral arteries. The level of systolic BP in a subgroup 1 associated with level PPG (r = 0,59; p < 0,05), body mass index (r = 0,49; p < 0,05), level of diastolic BP (r = 0,78; p < 0,05) than in subgroup 2 and 3.