PP.10.08

Abstract

Objective: The change of blood pressure (BP) with age is well established. The trajectory of BP with ageing using repeated data is less studied, and difference in longitudinal BP curves could contribute the population specific rates of age-dependent outcomes. We investigated the trajectory of BP in serial measurements in ageing population sample in Russia. Design and method: The representative population samples of men and women aged 45–69 years at baseline were examined in 2003/05 in Novosibirsk (Russia) and re-examined 3 years later (aged 48–72 years, response rate = 77%) as part of the HAPIEE Project. Two types of analyses were made: (i) cross-sectional analyses of BP vs. age, and (ii) longitudinal analyses of repeated measurements of BP in 5564 persons with two repeated measurements over a mean 3.1 (SD 0.7) year follow-up. The difference (DIFF) in BP values between two examinations was calculated. Results: In cross-sectional analyses of re-examination data, both SBP and DBP increased with age (b = 0.882 and b = 0.093, respectively, both p-values < 0.001). In longitudinal analyses over the follow up, the mean systolic (SBP) and diastolic blood pressure (DBP) increased by 5.3 and 1.5 mm Hg, respectively. The increases in SBP were similar in men and women but changes of DBP in men were not statistically significant. After restricting analysis to those not receiving antihypertensive treatment, SBP trajectory remained consistently upward and DBP trajectory became insignificantly downward. The curves of both SBP DIFF and DBP DIFF were decreasing (b = -0.191, p < 0.001 and b = -0.053, p = 0.021, respectively). Conclusions: In this Russian population sample of middle aged and older persons, SBP increased with age in both cross-sectional and longitudinal analyses. However, association of longitudinal DBP with age was not statistically significant. These findings reflect the limitations of BP control, and may suggest the peculiarities of BP gradient with ageing in the Siberian population; this might contribute the high rates of age-dependent outcomes.