PP.09.30] AN EXTENDED ONE-DIMENSIONAL ARTERIAL NETWORK MODEL FOR THE SIMULATION OF PRESSURE AND FLOW IN UPPER AND LOWER LIMB EXTREMITIES

Abstract

Objective: Arterial pulse wave velocity and pulse waveform analysis have become an established component of cardiovascular research. As validation and assessment of devices is not always trivial in an in vivo setting, arterial network computer models may be useful for that purpose. It is, however, mandatory that the model includes sufficient detail, especially when analysing peripheral waveforms. To extend the existing 1D arterial network model (103 segments) of Reymond et al. to a more detailed model (143 segments) including the foot and hand circulation (radial and tibial arteries). The goal is to (i) extend the existing 1D arterial network model (103 segments) of Reymond et al. to a more detailed model (143 segments) including the foot and hand circulation (Radial and Tibial arteries); (ii) use the extending model as testing tool for pOpmètre® (finger – toe pulse wave velocity). Design and method: The arterial tree dimensions and properties were taken from the literature and completed with data from patient scans. The model solves the one-dimensional form of the Navier-Stokes equations over each arterial segment. A non-linear viscoelastic constitutive law for the arterial wall was considered. Results: Comparison of simulations with and without detailed hand and foot circulation demonstrate important differences in waveform morphology in the distal beds. The completed model predicts pressure and flow waves in the hand and foot arteries which are in good qualitative agreement with the published in-vivo measurements. The agreement is especially good for the shape and wave details of the flow wave, where all features are reproduced in a rather faithful manner. The correlation between ftPWV and aPWV was good and significant (R2 = 0.95). The Bland and Altman analysis, mean difference was 0.4 m/s, classifying the ftPWV as good agreement with reference method. Conclusions: The extended model yields realistic pressure and flow waveforms in arteries of the hand and the foot. After full validation, the extended model used to assess the performance of diagnostic and screening devices relying on peripheral hemodynamics signals, the pOpmètre® (finger – toe PWV), where the correlation with the refernce method showed a good agreement.