PP.07.26

Abstract

Objective: To compare the response to once-daily valsartan/amlodipine (Val/Aml, 80/5 mg) single-pill combination therapy according to sex in CHINA STATUS II. Design and method: 1,1312 patients (6456 (57%) men and 4856 (43%) women) were analyzed. Patients were treated for 8 weeks. The percentages of not achieving the target systolic blood pressure (SBP > = 140 mm Hg) or diastolic blood pressure (DBP > = 90 mm Hg) were compared in different age groups of men and women, respectively at the baseline, 4 weeks and 8 weeks after Val/Aml treatment. The mixed model hierarchically estimated changes of BP according to different age and gender at 4 weeks and 8 weeks after therapy. Results: At enrollment, SBP was lower in men (159.30 ± 12.31 mm Hg) than in women (160.00 ± 12.71 mm Hg, P = 0.003), whereas DBP was higher in men (96.40 ± 10.65 mm Hg) than in women (94.50 ± 10.72 mm Hg, P < 0.001). Whether male or female, the percentage of not achieving target SBP was increased with age; however, the percentage of not achieving target DBP was decreased with age. The percentage of not achieving target BP in female were less than those in male (57.41% vs. 59.59%, P < 0.05 at 4 weeks and 22.22% vs. 23.78%, P < 0.05, OR = 0.95, 95% CI = 0.90, 0.99 at 8 weeks after Val/Aml treatment). Compared with male after Val/Aml treatment, the decrease values of SBP were more in female (20.07 ± 11.97 vs. 19.62 ± 11.07 mm Hg, P < 0.0001 at 4 weeks and 27.68 ± 12.56 vs. 26.74 ± 11.93 mm Hg, P = 0.0003 at 8 weeks), while the decrease values of DBP in female were less (P = 0.0009 and P < 0.0001). The mixed model analysis showed that the difference in SBP was closely related with sex, that lower SBP effect in female was better than it in male after Val/Aml treatment. The difference in DBP was closely related with age. Conclusions: Gender might be a factor to be taken in the individualized antihypertensive therapy.