Abstract
Objective: The purpose of this study was to investigate the relationship between insulin resistance and left ventricular (LV) hypertrophy in hypertensive patients. Design and method: We studied 1019 hypertensive patients (46,5% men, mean age 56,8 ± 11 year old), newly diagnosed untreated hypertension or under hypertension (mean systolic/diastolic arterial pressure 150,5 ± 21/93,3 ± 12,3 mmHg). In all patients BMI (mean 28 ± 1,5 kg/m2) and waist circumference (98 ± 3 cm) were measured. Fasting blood samples were taken for the evaluation of serum glucose and insulin at baseline and in 120 minutes after oral administration of 75 grams of glucose. Moreover, All patients were assessed by ultrasonography for left ventricle mass index (LVMI) measurement. Based on the presence or not of LV hypertrophy the population of the study was divided in two groups (group A: LVMI = < 115 g/m2 for men and = < 95 g/m2 for women, group B: LVMI > 115 g/m2 for men and > 95 g/m2 for women).Conclusions: Insulin resistance after oral glucose intake was significantly higher in hypertensive patients with LV hypertrophy compared with control.
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