PP.04.12

Abstract

Objective: Microalbuminuria (MA) is known to predict the onset of clinical proteinuria and chronic renal failure in diabetes mellitus. More recently, MA has been found to be an independent risk factor for cardiovascular disease in non diabetic populations. The present study was designed to investigate the prevalence of microalbuminuria and factors that associate with urine excretion of albumin in the population of Blida. Design and method: 2920 Participants in our specialized consultation were enrolled in this study. Besides the routine checkup program (an interview regarding health status, physical examination, chest X-ray, electrocardiography, and laboratory assessment of cardiovascular risk factors). For MA, spot urine samples were collected in the early morning and microalbuminuria was defined as, a urinary albumin excretion between 30 and 300 mg/l. These patients also underwent determination of ambulatory blood pressure monitoring. All calculations and statistical analyzes are processed by the SPSS 17.0. Results: The prevalence of MA in hypertensive population was 32%.The blood pressure of participants was 138 ± 16/78 ± 13 mmHg and 39.8% and 14.1% of participants were with hypertension and diabetes mellitus, respectively. Urine albumin was detected in 40.1% of cases. Mean age of 59.71 ± 13.56 years. Body mass index was > 30 kg/m2 in 58.2% of cases. Prevalence of Hyperglycemia was 23% with MA> 30 mg/l. Multivariate regression analysis revealed that abnormal albuminuria was correlated with systolic blood pressure, estimated 24 hours urinary salt excretion, and fasting plasma glucose after adjustment for possible factors (p < 0.0001). Conclusions: The prevalence of microalbuminuria increases with increase in age, body mass index and duration of hypertension. From this study, it is conceived that MA can be used as a predictor of future cardiovascular events in hypertensive patients.