PP.03.33

Abstract

Objective: To investigate the impacts of amlodipine, valsartan and the two drugs combination on blood pressure variability(BPV) and pulse wave velocity(PWV) Design and method: It's a prospective,open, parallel control study.119 participants who were newly diagnosed essential hypertension or receiving single antihypertensive drug were recruited and divided into three groups (amlodipine, valsartan and two drugs combination treatment). Each patient's relevant demographic data and laboratory indicators were collected, in line with his/her 24 hours ambulatory blood pressure monitoring and brachial ankle pulse wave velocity monitoring taken. All participants were given treatment respectively for 10 weeks, and then rechecked the baseline indicator, comparing their effects on BPV and PBV. Results: Amlodipine can most effectively reduce 24-hour systolic blood pressure variability and diurnal systolic blood pressure variability. Amlodipine is the most effective and valsartan is the least in terms of reducing 24-hour diastolic blood pressure variability(P < 0.05).Three kinds of antihypertensive scheme can reduce arterial stiffness (baPWV), degree from strong to weak is: valsartan, two drug combination, amlodipine. The relationship between baPWV and 24 h average systolic blood pressure, 24 h systolic/diastolic blood pressure variability, 24 h average pulse pressure, daytime highest/average systolic blood pressure, daytime systolic/diastolic blood pressure variability, daytime highest diastolic blood pressure, daytime average pulse pressure, nighttime minimum systolic blood pressure are all positively correlated (P < 0.05 or P < 0.01).Between baPWV and nocturnal systolic blood pressure drop rate is a positive correlation (P < 0.05). The relationship between baPWV and nighttime diastolic blood pressure drop rate, however, has no statistical significance. Conclusions: Three treatments can all effectively control blood pressure. Amlodipine has the strongest antihypertensive effect and can effectively reduce BPV. Valsartan has independent effect in improving arterial stiffness. Arterial stiffness is associated with blood pressure levels and BPV, and its relationship between systolic blood pressure is greater than diastolic blood pressure.