Abstract
Nanomagnetic materials offer exciting avenues for advancing cancer therapies. Most researches have focused on efficient delivery of drugs in the body by incorporating various drug molecules onto the surface of nanomagnetic particles. The challenge is how to synthesize low toxic nanocarriers with multi-target drug loading. The cancer cell death mechanisms associated with those nanocarriers remain unclear either. Following the cell biology mechanisms, we develop a liquid photo-immobilization approach to attach doxorubicin, folic acid, tumor necrosis factor-α, and interferon-γ onto the oleic acid molecules coated Fe3O4 magnetic nanoparticles to prepare a kind of novel inner/outer controlled multi-target magnetic nanoparticle drug carrier. In this work, this approach is demonstrated by a variety of structural and biomedical characterizations, addressing the anti-cancer effects in vivo and in vitro on the HeLa, and it is highly efficient and powerful in treating cancer cells in a valuable programmed cell death mechanism for overcoming drug resistance.
Highlights
Nanomagnetic materials offer exciting avenues for advancing cancer therapies
These experiences motivate us to argue that oleic acid (OA)-Magnetic nanoparticles (MNPs) with photo-immobilized DOX, folic acid (FOL), tumor necrosis factor-a (TNF-a) plus IFN-c could remarkably enhance the inhibition to human cervical cancers
The general procedure for photo-immobilizing these drugs with the oleic acid coated MNPs (OAMNPs) is presented in Fig. 1b, while Figs. 1c and 1d show the solid photo-immobilization (SPI) and liquid photo-immobilization (LPI) schemes
Summary
Nanomagnetic materials offer exciting avenues for advancing cancer therapies. Most researches have focused on efficient delivery of drugs in the body by incorporating various drug molecules onto the surface of nanomagnetic particles. Following the cell biology mechanisms, we develop a liquid photo-immobilization approach to attach doxorubicin, folic acid, tumor necrosis factor-a, and interferon-c onto the oleic acid molecules coated Fe3O4 magnetic nanoparticles to prepare a kind of novel inner/outer controlled multi-target magnetic nanoparticle drug carrier. In this work, this approach is demonstrated by a variety of structural and biomedical characterizations, addressing the anti-cancer effects in vivo and in vitro on the HeLa, and it is highly efficient and powerful in treating cancer cells in a valuable programmed cell death mechanism for overcoming drug resistance. These experiences motivate us to argue that OA-MNPs with photo-immobilized DOX, FOL, TNF-a plus IFN-c could remarkably enhance the inhibition to human cervical cancers
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