Power of the adjusted Q statistic to evaluate heterogeneity in meta-analyses of cluster randomized trials

Abstract

ABSTRACTBecause of its simplicity, the Q statistic is frequently used to test the heterogeneity of the estimated intervention effect in meta-analyses of individually randomized trials. However, it is inappropriate to apply it directly to the meta-analyses of cluster randomized trials without taking clustering effects into account. We consider the properties of the adjusted Q statistic for testing heterogeneity in the meta-analyses of cluster randomized trials with binary outcomes. We also derive an analytic expression for the power of this statistic to detect heterogeneity in meta-analyses, which can be useful when planning a meta-analysis. A simulation study is used to assess the performance of the adjusted Q statistic, in terms of its Type I error rate and power. The simulation results are compared to that obtained from the proposed formula. It is found that the adjusted Q statistic has a Type I error rate close to the nominal level of 5%, as compared to the unadjusted Q statistic commonly used to test for heterogeneity in the meta-analyses of individually randomized trials with an inflated Type I error rate. Data from a meta-analysis of four cluster randomized trials are used to illustrate the procedures.