Abstract
Since the discovery by Glick approximately 40 years ago of the role of bursa of Fabricius in antibody production, research by poultry scientists has continued to add to our knowledge and understanding of basic immunological concepts. The role of nonlymphoid cells--namely cells belonging to the mononuclear phagocytic system lineage in antigen uptake and processing and mediating cellular interactions--is currently an active area of research in animal and human immunology. The mechanisms and pathways are being defined which enable chicken macrophages to perform their effector functions such as phagocytosis, bacterial and tumor cell killing. In addition, nutritional, physiological and genetic parameters are being examined to potentiate the first line of immunological defense by enhancing macrophage functions. These research efforts would benefit the poultry industry in raising chickens with improved disease resistance potential. At the same time, the knowledge of macrophage function pathways would broaden our understanding of the overall role which the immune system plays both in human and animal health.
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