Abstract
When liberated in base form, antihistamines may be dissolved in alcohol and titrated directly with 0.05 N aqueous sulfuric acid, or dissolved in a measured volume of the acid and the excess titrated with 0.05 N aqueous sodium hydroxide; the end point is determined potentiometrically. A much simpler and more precise method is that of direct titration of either the base or salt form of antihistamines, dissolved in glacial acetic acid, with 0.1 N perchloric acid in dioxane; the end point is preferably determined potentiometrically but may also be determined colorimetrically. Interference by the halide acid component of salts is avoided by addition of mercuric acetate.
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