Potentiometric titration for the high precision determination of active components in six types of chemical disinfectants.

Jiansheng Liang,Lin Gong,Xiaoli Liu,Bin Wang,Junsheng Zhu,Thomas Webster

doi:10.1371/journal.pone.0203558

Jiansheng Liang, Lin Gong + Show 4 more

Open Access

https://doi.org/10.1371/journal.pone.0203558

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Journal: PloS one	Publication Date: Sep 7, 2018
Citations: 4	License type: CC BY 4.0

Affiliation: Wuhan Center for Disease Control and Prevention

Abstract

Chemical disinfectants effectively kill pathogenic microorganisms, eliminating routes of transmission for infectious diseases. Accurate quantification of the active ingredients can help make a more effective use of disinfectants. In this study, the active ingredients in six different types of chemical disinfectants were systematically quantified with great precision and accuracy using potentiometric titration. The coefficient of variations fell in the range of 0.04%-0.46%. The recovery rates of samples were all above 95% and the extended uncertainty was 0.32g/L. This method can be broadly applied to the analysis of disinfectants in the future.

Highlights

Chemical disinfectants effectively kill or remove pathogenic microorganisms, blocking disease transmission routes[1]
The results of potentiometric titration and direct titration were shown in Table 1. there were no significant differences between the two methods (P>0.05).This indicated that the analysis of chemical disinfectants by potentiometric titration agrees with the current National Standard. the coefficient of variation (CV) for the effective content in chemical disinfectants determined by potentiometric titration were lower than those obtained using the other method, except for the bromogeramine disinfectant, suggesting that potentiometric titration has a superior precision direct titration
In classical chemical titration, the endpoint is based on the color change of an indicator

Summary

Introduction

Chemical disinfectants effectively kill or remove pathogenic microorganisms, blocking disease transmission routes[1]. Used chemical disinfectants include chlorine compounds, iodine, oxidants, aldehydes, alcohols, and quaternary ammonium salts[2]. The efficacy of these chemical disinfectants to eliminate microbes can be affected by many factors[3], of which the content of the active component of the disinfectant is clearly the most critical one. The most commonly used techniques for determining the content of chemicals include volumetric analysis, spectrophotometry, gas chromatography, and high-performance liquid chromatography [4,5,6,7]. Potentiometric titration[8]is used to determine the effective content of general chemical disinfectants from six different categories. The testing and results of potentiometric titration are discussed

Methods

Results

Conclusion