Abstract
The dissociation behavior of a copolymer of glutamic acid and alanine was investigated by means of potentiometric titration at various ionic strengths. From the curves of the apparent dissociation constants versus the degree of dissociation, the intrinsic dissociation constant of the carboxyl groups in the copolymer was estimated to be 3.92. This value is different from that of α-linked polyglutamic acid and is similar to those of γ-linked polyglutamic acids such as bacterial poly-γ-D-glutamic acid. An analytical method of titration was used to determine the ratio of α- and γ-glutamyl residues in the copolymer. From the results of this method and from the intrinsic dissociation constant, it was concluded that the glutamyl residues in this copolymer are mostly or entirely γ-linked.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
