Abstract
AbstractA poly(vinyl chloride) (PVC) membrane potentiometric sensor was developed for the determination of anti‐epileptic drug levetiracetam. For this purpose, levetiracetam‐tetraphenylborate (LEV‐TPB) ion‐pair was synthesized and the synthesized ion‐pair was used as ionophore in PVC membrane structures. The membrane composed of 3.0 % (w/w) LEV‐TPB ion‐pair, 32.0 % (w/w) PVC, and 65.0 % (w/w) o‐nitrophenyloctylether (o‐NPOE) was determined as the membrane with the best potentiometric properties. The developed sensor exhibited a linear response in the concentration range from 1.0×10−5 to 1.0×10−1 mol L−1 and had a detection limit of 6.31×10−6 mol L−1. For this sensor, pH working range and response time were determined as 6.0–8.0 and ≈25 s, respectively. The sensor displayed a good selectivity for levetiracetam in the presence of a number of common ionic species and some anti‐epileptic drug. The proposed levetiracetam‐selective sensor was successfully applied for the determination of levetiracetam in pharmaceutical drug samples which is used in the treatment of epilepsy.
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