Potentiometric Multisensory Systems with Novel Ion-Exchange Polymer-Based Sensors for Analysis of Drugs

Olga V Bobreshova,Anna V Parshina,Ksenia A Polumestnaya

doi:10.1155/2012/392735

Olga V Bobreshova, Anna V Parshina + Show 1 more

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https://doi.org/10.1155/2012/392735

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Abstract

This paper examines potentiometric multisensory systems that consist of novel cross-sensitive PD-sensors (Potential Donnan-sensors). The analytical signal of PD-sensors is the Donnan potential at the ion-exchange polymer/electrolyte test solution interface. The use of novel sensors for the quantitative analysis of multicomponent aqueous solutions of amino acids, vitamins and medical substances is based on protolytic and ion-exchange reactions at the interfaces of ion-exchangers and test solutions. The potentiometric sensor arrays consist of PD-sensors and ion-selective electrodes. Such systems were developed for the multicomponent quantitative analysis of lysine monohydrochloride, thiamine chloride and novocaine hydrochloride solutions that contained salts of alkaline and alkaline-earth metals, as well as for mixed solutions of nicotinic acid and pyridoxine hydrochloride. Multivariate methods of analysis were used for sensor calibration and the analysis of the total response of sensor arrays. The errors of measurement of the electrolytes in aqueous solutions did not exceed 10%. The developed multisensory systems were used to determine the composition of a therapeutic “Mineral salt with low content of sodium chloride” and to determine concentrations of novocaine in sewage samples from a dental clinic.

Highlights

IntroductionUV spectrophotometry [1], spectrofluorimetry [2], and HPLC [3] are commonly used methods for the quantitative analysis of amino acids, vitamins, and medical substances in aqueous solutions
UV spectrophotometry [1], spectrofluorimetry [2], and HPLC [3] are commonly used methods for the quantitative analysis of amino acids, vitamins, and medical substances in aqueous solutions.The advantages of potentiometric methods include the possibility of rapid, in situ analysis, the automation and separation of measurements, the simplicity of the technique, and the absence of any probe preparation [4,5,6]
We have previously described the application of the PD sensor for the selective determination of lysine in the presence of neutral amino acids, ammonium ions [28, 32], and PD sensors, which are cross-sensitive in multicomponent solutions of some amino acids, vitamins, medicinal substances, and inorganic salts [29, 30, 33]

Summary

Introduction

UV spectrophotometry [1], spectrofluorimetry [2], and HPLC [3] are commonly used methods for the quantitative analysis of amino acids, vitamins, and medical substances in aqueous solutions. We described the development of a novel potentiometric sensor (PD sensor), which measures the Donnan potential at an ion-exchange polymer (IEP)/electrolyte test solution interface [28,29,30,31,32,33]. The use of the membrane potential equilibrium constant as an analytical signal, which is the Donnan potential at the IEP/test solution interface, allows us to eliminate issues related to migration and diffusion in ionophore-based potentiometric sensors [16, 17]. This process increases the accuracy, stability and sensitivity of organic and inorganic ion measurements. The analytes of interest were amino acids, vitamins, and medical substances

Experimental

Results and Discussion

Conclusion