Abstract
Bromhexine hydrochloride ion-selective electrodes (conventional type) based on bromhexinium tetraphenyl borate (I) and bromhexinium-phosphotungstate (II) were prepared. The electrodes exhibited mean slopes of calibration graphs of 59.4 mV and 59.8 mV per decade of bromhexine concentration at 25°C for electrode (I) and (II), respectively. Both electrodes could be used within the concentration range 3.16x10-5-1.00x10-2 M bromhexine within the pH range 2.0-4.5. The standard electrodes potentials were determined at different temperatures and used to calculate the isothermal coefficients of the electrodes, which were 0.00065 and 0.00050 V°C-1 for (I) and (II), respectively. The electrodes showed a very good selectivity for bromhexine with respect to a number of inorganic cations, amino acids and sugars. The electrodes were applied to the potentiometric determination of bromhexine hydrochloride and its pharmaceutical preparation under batch and flow injection conditions. Graphite, copper and silver coated wires were prepared, characterized and successfully applied as sensors for the drug under investigation.
Highlights
Key words Ion-selective electrodes, bromhexine hydrochloride, conventional and coated wire electrodes, flow injection analysis and conductimetry
In the present work, plastic membrane electrodes, selective for bromhexine hydrochloride are constructed, their performance characteristics studied and used to determine the drug both in batch and with a flow injection technique, which is considered a very efficient way of improving the performance characteristics of Ion-Selective Electrode (ISE)
The electrodes are based on the incorporation of bromhexinium tetraphenylborate (Brom-TPB) and bromhexinium phosphotungstate (Brom-PT) ionexchangers in poly (PVC) membranes plasticized with dibutylphthalate (DBP)
Summary
Key words Ion-selective electrodes, bromhexine hydrochloride, conventional and coated wire electrodes, flow injection analysis and conductimetry. Plastic membrane electrodes, selective for bromhexine hydrochloride are constructed, their performance characteristics studied and used to determine the drug both in batch and with a flow injection technique, which is considered a very efficient way of improving the performance characteristics of ISEs. The electrodes are based on the incorporation of bromhexinium tetraphenylborate (Brom-TPB) and bromhexinium phosphotungstate (Brom-PT) ionexchangers in poly (vinyl chloride) (PVC) membranes plasticized with dibutylphthalate (DBP).
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