Abstract
BackgroundThe construction and electrochemical response characteristics of Poly (vinyl chloride) membrane sensors for moxifloxacin HCl (MOX) are described. The sensing membranes incorporate ion association complexes of moxifloxacin cation and sodium tetraphenyl borate (NaTPB) (sensor 1), phosphomolybdic acid (PMA) (sensor 2) or phosphotungstic acid (PTA) (sensor 3) as electroactive materials.ResultsThe sensors display a fast, stable and near-Nernstian response over a relative wide moxifloxacin concentration range (1 × 10−2 - 4.0 × 10−6, 1 × 10−2 - 5.0 × 10−6, 1 × 10−2 - 5.0 × 10−6 M), with detection limits of 3 × 10−6, 4 × 10−6 and 4.0 × 10−6 M for sensor 1, 2 and 3, respectively over a pH range of 6.0 - 9.0. The sensors show good discrimination of moxifloxacin from several inorganic and organic compounds. The direct determination of 400 μg/ml of moxifloxacin show an average recovery of 98.5, 99.1 and 98.6% and a mean relative standard deviation of 1.8, 1.6 and 1.8% for sensors 1, 2 and 3 respectively.ConclusionsThe proposed sensors have been applied for direct determination of moxifloxacin in some pharmaceutical preparations. The results obtained by determination of moxifloxacin in tablets using the proposed sensors are comparable favorably with those obtained using the US Pharmacopeia method. The sensors have been used as indicator electrodes for potentiometric titration of moxifloxacin.
Highlights
The construction and electrochemical response characteristics of Poly membrane sensors for moxifloxacin HCl (MOX) are described
It seems that o-nitrophenyl octylether (NPOE) improves the membrane selectivity due to its high dialectical constant (ε = 24), affects considerable dissolution of ion-association within the membrane; enhances its partition coefficient in the membrane and provided suitable mechanical property of the membrane compared with less permittivity plasticizers of dibutyl sebacate (DBS) (ε = 4) or dioctyl phthalate (DOP) (ε = 7) and the solubility of electroactive materials are relatively small compared with NPOE
Sodium tetraphenyl borate, phosphomolybdic acid, and phosphotungstic acid were tested as ion-pairing agent for the preparation of electroactive ion association complexes for MOX
Summary
The sensors display a fast, stable and near-Nernstian response over a relative wide moxifloxacin concentration range (1 × 10−2 - 4.0 × 10−6, 1 × 10−2 - 5.0 × 10−6, 1 × 10−2 - 5.0 × 10−6 M), with detection limits of 3 × 10−6, 4 × 10−6 and 4.0 × 10−6 M for sensor 1, 2 and 3, respectively over a pH range of 6.0 - 9.0. The sensors show good discrimination of moxifloxacin from several inorganic and organic compounds. The direct determination of 400 μg/ml of moxifloxacin show an average recovery of 98.5, 99.1 and 98.6% and a mean relative standard deviation of 1.8, 1.6 and 1.8% for sensors 1, 2 and 3 respectively
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