Abstract
A potentiometric titration method for the determination of minoxidil based on its redox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.
Highlights
Minoxidil (2,4-diamino-6-piperidinopyrimidine-3-oxide) is an odorless white crystalline powder, insoluble in water, acetone or alkaline solutions, slightly soluble in alcohols, and freely soluble in acidic solutions [1]
Concerning analytical methods, MnO4- has been proposed for the oxidimetric titration of minoxidil [2,7,8]
The commercial samples used in this work were Regaine® from Pharmacia (USA) and Neoxidil® from Galderma (Brazil); both purchased in the local market
Summary
Minoxidil (2,4-diamino-6-piperidinopyrimidine-3-oxide) is an odorless white crystalline powder, insoluble in water, acetone or alkaline solutions, slightly soluble in alcohols, and freely soluble in acidic solutions [1]. It has been used as a peripheral vasodilator drug orally administrated, applied in the treatment of refractory hypertension patients [2] and liquid retention and hirsutism is being observed for excessive doses [3]. Minoxidil shows new applications in dermatology, especially in the treatment of androgenic alopecia [3,4] In this case, this drug has been topically applied in order to stimulate hair growth by inducing vasodilatation and increasing the local irrigation and blood flow [4]. Most of them are based in chromatographic methods as described in references [3, 9 – 12]
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