POTENTIOMETRIC DETERMINATION OF GLYCOPYRRONIUM BROMIDE IN BINARY MIXTURE WITH INDACATEROL MALEATE USING POLYVINYL CHLORIDE (PVC) MEMBRANE, COATED GRAPHITE AND CARBON PASTE SENSORS

Mohammed El Dosoky

doi:10.21608/ajps.2018.46632

Abstract

A novel approach was conducted in this article for the determination of glycopyrronium bromide (GLY) in binary mixture with indacaterol maleate using ion selective electrodes for its selective determination in pure form and pharmaceutical formulation. Four ion selective electrode sensors were designed for determination of glycopyrronium bromide namely; glycopyrronium bromide-polyvinyl chloride (GLY-PVC) membrane, GLY-Coated graphite sensor and GLY-modified carbon paste sensors. The sensors are based on the ion association complexes of GLY cation with sodium tetra phenyl borate (GLY-TPB) and phosphomolybidic acid (GLY-PMA) counter anions as ion exchange sites using dioctylphthalate (DOP) as plasticizer. Validation of the method shows suitability of the proposed sensors for use in the quality control assessment of GLY and for its routine analysis. The results obtained were statistically compared to reported method and there was no significant difference between the proposed methods and the reported method regarding the accuracy and precision. The method was validated according to International Conference on Harmonization (ICH) guidelines and the results were satisfactory.

Highlights

Glycopyrronium bromide (GLY) is 3-(2-cyclopentyl-2-hydroxy-2phenylacetoxy)-1,1- dimethylpyrrolidinium bromide (Figure 1)
In the present study three types of ion selective membrane electrodes, poly vinyl chloride (PVC), coated graphite and modified carbon paste sensors have been constructed for selective determination of glycopyrronium bromide
The methods are based on the fact that, glycopyrronium bromide behaves as a cation with an anionic type of ion exchanger such as tetraphehylborate and phosphomolybidic acid to prepare water insoluble association complexes using precipitation based technique

Summary

Introduction

Glycopyrronium bromide (GLY) is 3-(2-cyclopentyl-2-hydroxy-2phenylacetoxy)-1,1- dimethylpyrrolidinium bromide (Figure 1). The most widely used solid membrane electrodes are the plasticized poly vinyl chloride (PVC) electrodes which are based on the formation of ion-associates between drugs and counter ions, the formed ion-associate was used together with PVC and a suitable plasticizer in preparation of the membrane electrode. Liquid membranes are formed from immiscible liquids that selectively bond certain ions. The liquid ion-exchanger may be retained in a porous inert solid support, which separates the liquid electrode inner solution from the test solution (Moody et al, 1988 & Ragab et al, 2015)

Methods

Results

Conclusion