Abstract
SHIPLEY, W. U., ELKIND, M. M., AND PRATHER, W. B. Potentiation of Xray Killing by 5-Bromodeoxyuridine in Chinese Hamster Cells: A Reduction in Capacity for Sublethal Damage Accumulation. Radiat. Res. 47, 437-449 (1971). Chinese hamster cells grown, treated, and assayed in culture were used to study the enhanced cell killing that results when cells are irradiated containing the thymidine analogue 5-bromodeoxyuridine. Under exponential growth conditions, which probably result in unifilar or bifilar substituted DNA, such cells have reduced ability to recover between two fractionated doses. Studies with synchronized, maximally resistant, late S-phase cells confirmed that the main effect of 5-bromodeoxyuridine incorporation is to reduce a cell's capacity to accumulate sublethal damage rather than to
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