Abstract
The presence of hydroxyurea (HU) during G2 potentiated the yield of chromatid-type aberrations induced by X-rays and Streptonigrin in human lymphocytes. A potentiating effect of the same type and magnitude was obtained, when caffeine was given as a post-treatment during G2. It was further demonstrated that the X-ray-induced mitotic delay was shortened by caffeine and prolonged by HU. The results indicate that there is a process for repair of DNA damage late in G2 and that chromatid aberrations may be produced when this repair process fails or makes mistakes. Both caffeine and HU are believed to reduce the efficiency of the repair process; caffeine by shortening the time available for repair and HU by reducing the supply of material required for repair.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
