Abstract
The anti-tumor drug bleomycin reduces the activity of DNA-dependent DNA polymerase in isolated enzyme system as well as the cell proliferation by fragmentation of the DNA. These two test systems were used to determine the effect of the A·T-specific DNA ligands, steffimycin B and Hoechst 33258, on the activity of bleomycin. It has been found that both the inhibitory effect of bleomycin on the DNA-dependent DNA polymerase and the one on cell proliferation are potentiated when bleomycin is given in combination with steffimycin B or with Hoechst 33258.
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