Abstract
An investigation was made into the effects of local administration of various anti-cancer drugs during contact sensitization on the development of delayed hyper-sensitivity. Low doses of cell-cycle non-specific drugs, particularly some recently synthesized cyclophosphamide-derivatives that do not require liver conversion for their action, showed strong effector T-cell immunopotentiation. The value of this phenomenon in the treatment of malignancies is stressed, as our data imply that properly scheduled local chemotherapy may simultaneously facilitate the development of systemic immunity.
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