Abstract
This study investigated in mice the interactions between drugs commonly used in chronic, multiple drug therapy in asthma. Pretreatment for three days with phenobarbital before injecting theophylline decreases blood xanthine levels. However, the phenothiazine derivatives, promazine or chlorpromazine when concurrently injected intraperitoneally with the xanthine derivatives, theophylline or aminophylline, elevated blood xanthine levels. These results suggest that certain phenothiazines may be of value in acute antiasthmatic therapy because they increase blood xanthine levels as well as being CNS depressants. Furthermore, phenothiazines in combination with aminophylline or theophylline in acute administration have the added advantage of markedly potentiating the increase in plasma cyclic AMP reflecting higher blood theophylline levels. It has been suggested that increased cyclic AMP may prevent the release of bronchoconstrictor substances by ensuring the integrity of mast cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: European Journal of Drug Metabolism and Pharmacokinetics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
