Abstract
AbstractBoth maleic acid and succinic acid enhance anaphylactic histamine release from guinea pig lung in vitro–the degree of enhancement being of the same order of magnitude. The stimulating effect of both the substrates is inhibited by relatively low concentrations of malonic acid and bromopyruvic acid, and no stimulation occurs in response to either substrate when histamine is released by the antigen in an anaerobic medium. Maleic acid is shown to be metabolized to CO2 by guinea pig lung nearly at the same rate as the tissue oxidizes succinic acid to CO2–the conversion of both the substrates to CO2 beifig inhibited by malonic acid. Furthermore, D (+) malic acid has been identified as an intermediate product in the metabolism of maleic acid by guinea pig lung. It is suggested that maleic acid follows the same metabolic pathway in guinea pig lung as revealed earlier in rabbit kidney, viz. maleic acid → D (+) malic acid → oxaloacetic acid → CO2. The findings thus suggest that both maleic acid and succinic acid enhance anaphylactic histamine release from guinea pig lung through their metabolic utilization in the tricarboxylic acid cycle.
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