Potentiation by cocaine and 3,3-di(p-aminophenyl)-propylamine (TK 174) of the effect of isoprenaline and noradrenaline on isolated strips of cat spleen.

Abstract

Abstract Contractions of cat isolated spleen strips by noradrenaline and isoprenaline are brought about by interaction with α-adrenergic receptors. The effect of isoprenaline cannot be diminished by in vivo reserpine pretreatment. The effects of both noradrenaline and isoprenaline are potentiated by cocaine and by a new diphenyl-propylamine derivative TK 174 [3,3-di(p-aminophenyl)propylamine]. Noradrenaline is potentiated more by TK 174 than by cocaine while the reverse is seen with isoprenaline. These results suggest that beside the inhibition of noradrenaline uptake another factor may be involved in the mechanism of action of cocaine, and to a lesser extent of TK 174.