Abstract
The study aimed to investigate the in vitro antifungal activity of miconazole entrapped in microemulsion based gel with clove oil as permeation enhancer and chitosan as antifungal agent. SEM confirmed spherical droplets of microemulsion in the 2 micron size range. The viscosity of emugel was 2251 cP, excellent spreadability 31.27 ±0.219 g.cm/cc as compared to marketed formulation. pH was 5.528 ± 0.032, homogeneity was excellent and drug content was 98 % in optimized batch. No drug-excipients interaction was reported in FTIR spectroscopy. In vitro drug release showed 94.8 % in 6 h. Ex vivo skin permeation showed higher steady state flux than conventional cream. Antifungal activity on Candida albicans showed a zone of inhibition more than that of marketed preparation. Thus, it can be concluded that the formulation may hold some promise for the treatment of severe fungal infections.
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