Abstract
It has been shown in earlier reports that the injection of insulin into chicken eggs leads to the appearance of embryo malformations. The kind of abnormality which insulin induces varies with the developmental stage during which embryos are exposed to the hormone. The principal effect of such treatment before the beginning and during the first 48 hours of incubation is rumplessness (Landauer, 1945). At later stages, especially during the fourth and fifth days of development, insulin chiefly induces micromelia and defects of the beak (Landauer, 1947). It seemed of interest to determine whether or not other hormones have similar teratogenic properties and also what their possible interaction with insulin might be. The experiments on which we wish to report here were concerned with epinephrine and adrenal cortical extract and with tests in which one of these adrenal hormones was, either at the same time or after an interval of 24 hours, combined with insulin treatment.
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