Potentiated Sulfonamide Therapy of Aeromonas hydrophila Infection in Channel Catfish

Abstract

Abstract Four trials were conducted to establish the therapeutic efficacy of Romet(TM) in the control of experimentally induced Aeromonas hydrophila infection in channel catfish (Ictalurus punctatus). Romet dose levels tested were 25, 50, 75, and 100 mg active ingredient per kilogram of fish body weight. Administration of medicated feed started on the day prior to infection and continued for four consecutive days, followed by 14 d posttreatment observation. Analysis of the pooled data showed a significant (P < 0.01) reduction in mortality between the medicated and nonmedicated groups. There were no differences in mortality between any of the medicated groups. The safety and palatability of Romet-medicated feed was evaluated for fingerling channel catfish. In one trial, regimens of 0, 50, 100, 200, and 400 mg Romet/kg of fish body weight were each administered to three aquaria of 10 fish each for 14 consecutive days. In another trial, treatment regimens of 0 and 1,250 mg Romet/kg body weight were administe...