Abstract
Potentials of Glycoprotein Fraction in Successful Diagnosis of Sheep Haemonchosis
Highlights
Haemonchus contortus is a nematode parasite found in abomasum of sheep and goat, and feeds on blood (Edwards et al, 2016; Wang et al, 2017; Almeida et al, 2018)
The attention of scientists has been focused on identification of immunogenic proteins to control of H. contortus infection and the possibility that parasite carbohydrate antigens can act as novel vaccine candidates (Paschinger andWilson,2015).Many studies in which many isolated glycoproteins H. contortus antigens were used for protection against H. contortus infection (Kalyanasundaram et al, 2015; Teixeiraet et al, 2019; Nobre et al, 2020)
Purification of H. contortus adult worms antigen by con Aaffinity column chromatography resulted in four fractions; D- Glucose, D- Galactose, N-Acetylglucoseamine and Lactose fractions
Summary
Haemonchus contortus is a nematode parasite found in abomasum of sheep and goat, and feeds on blood (Edwards et al, 2016; Wang et al, 2017; Almeida et al, 2018). H. contortus infection causes huge economic losses, profitability reduction of the ruminant industry due to weight loss, acute anemia, edema, diarrhea, and lowering in milk and wool production (Emery et al, 2016; Gadahi et al, 2016a).This infection becomes a life threatening disease disturbing sheep population (Besier et al, 2016), because of massive mortality and morbidity rate in affected young animals (Dey et al, 2018). The ultrastructure of nematodes demonstrates different structures responsible for expression the different carbohydrate-containing glycoconjugates on their body, and their excretion/secretion products rich in glycans (Hassanain et al, 2009). These glycans have significant biological roles in the host–parasite relationship
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