Abstract
Periodontal disease results in damage to dental insertion apparatus. Regenerative procedures are proposed to replace lost structures in the context of guided tissue regeneration (GTR), guided bone regeneration (GBR) techniques and frequently associate bone substitutes with physical barriers aiming at greater longevity and improvement of aesthetic pattern. This study evaluates the possibility of using glycerol as a starch films modifying agent, acting as a cross-linking agent, without compromising its plasticizing effect. Biodegradable cassava starch films were prepared incorporating glycerol at concentrations of 0, 15, 20, 30 and 40% aiming application at dental regenerative procedures. The characterization of films by microscopy (SEM), thermal analysis (DSC), spectroscopic (UV / Vis., FTIR, XRD), mechanical (Traction), and analysis of protein swelling, degradation and diffusion and physiological temperature) showed that the incorporation of glycerol in up to 20% attributed to the films a plasticizer character and in higher concentrations, conferred a greater interaction of glycerol (crosslinking) with the starch chains and a degradation time that allows the physical barrier in RTG and ROG. The films presented mechanical resistance, malleability and permissiveness to protein diffusion in the in vitro assays, which meet the current attributes that guide the use of these resources in biomaterials.
Highlights
Periodontal disease is characterized as a multifactorial chronic inflammatory disease associated with biofilm presenting clinically with loss of dental insertion apparatus (Pinheiro et al, 2021)
Regenerative procedures are proposed to replace lost structures in the context of guided tissue regeneration (GTR), guided bone regeneration (GBR) techniques and frequently associate bone substitutes with physical barriers aiming at greater longevity and improvement of aesthetic pattern
The characterization of films by microscopy (SEM), thermal analysis (DSC), spectroscopic (UV / Vis., fourier transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD)), mechanical (Traction), and analysis of protein swelling, degradation and diffusion and physiological temperature) showed that the incorporation of glycerol in up to 20% attributed to the films a plasticizer character and in higher concentrations, conferred a greater interaction of glycerol with the starch chains and a degradation time that allows the physical barrier in RTG and ROG
Summary
Periodontal disease is characterized as a multifactorial chronic inflammatory disease associated with biofilm presenting clinically with loss of dental insertion apparatus (Pinheiro et al, 2021). The treatment aims at interrupting the tissue destruction in which surgical interventions are presented with the purpose to promote root decontamination and adjust the periodontal structures through the resective and regenerative procedures. Considering the limitations of resective surgeries when using bone reconstructions to eradicate defects (Becker et al 2001), regenerative techniques are recommended based on improved function and prognosis in the long term, as well as improvement in the esthetic pattern (Boyne 1964). Gottlow et al, (1986), evaluated the stability of new periodontal insertion achieved through guided tissue regeneration (GTR). This principle, initially called Guided Bone Regeneration (GBR), was described by Hurley et al, in 1959. Studies describe the efficacy of the membranes together with the reconstructive treatment as the result of contact inhibition by the interaction of heterotopic cells in addition to the exclusion of soluble inhibitory factors derived from cells, favoring the local concentration of growth stimulating factors, even combined with properties stimulating the membrane itself (Linde et al, 1993; Andrade Silva et al, 2021)
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