Abstract
We have recently discovered that cancer cells take up extracellular citrate through plasma membrane citrate transporter (pmCiC) and advantageously use citrate for their metabolism. Citrate uptake can be blocked with gluconate and this results in decreased tumor growth and altered metabolic characteristics of tumor tissue. Interestingly, gluconate, considered to be physiologically neutral, is incidentally used in medicine as a cation carrier, but not as a therapeutically active substance. In this review we discuss the results of our recent research with available literature and suggest that gluconate may be useful in the treatment of cancer.
Highlights
Potential Use of Gluconate in Cancer TherapyJ. Mohr 2, Katharina Schmidt 1, Konstantin Drexler 3, Petra Rümmele 4, Sebastian Haferkamp 3, Hans J
Despite intense basic and clinical cancer research, progress in controlling and curing malignancies remains slow
Our work shows that cancer cells take up extracellular citrate through the plasma membrane citrate transporter belonging to the SLC25 family and that expression of this transporter is mainly restricted to cancer cells [14]
Summary
J. Mohr 2, Katharina Schmidt 1, Konstantin Drexler 3, Petra Rümmele 4, Sebastian Haferkamp 3, Hans J. Schlitt 1, Andreas Gaumann 5, Jerzy Adamski 6,7,8 and Edward K. Reviewed by: Mikhail Durymanov, Moscow Institute of Physics and Technology, Russia Stephanie Marie Bozonet, University of Otago, Christchurch,. Specialty section: This article was submitted to Cancer Molecular Targets and Therapeutics, a section of the journal
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