Abstract
Non-small cell lung cancer (NSCLC) is the most common type, with a high mortality rate. It is often diagnosed at anadvanced stage, which causes treatment difficulties due to a lack of symptoms at early stages. Here, we propose a newapproach for treating NSCLC via upregulating zinc finger protein 671 (ZNF671) expression. Firstly, we will reduce thedegree of methylation at its gene promoter site in the NSCLC tumor cells. Secondly, the RT-qPCR technique is usedto compare the expressions of ZNF671 between different methylation statuses; in vitro cell viability, proliferation, andinvasion assays are applied to test the effects of demethylation in tumor cells. Finally, the patient-derived xenografts(PDX) model is used to observe the effect of regulating methylation status on the expression of ZNF671, affecting tumorgrowth in vivo.
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