Abstract
Recently, nano titanium silicon oxide (TiSiO4 NPs) has been used in different fields and industries. Very few toxicological data exist for TiSiO4 NPs. In the present study, the potential adverse effects of oral exposure to a single dose of TiSiO4 NPs ≤ 50 nm (250 mg/kg b.w.) in adult male rats were investigated through the assessment of biomarkers for serum biochemical parameters, liver DNA damage, and histopathological examination and determination of Si and Ti in the exposed rat tissues. The results revealed that there were no significant changes in serum total protein, albumin, and triglycerides content, while total cholesterol level was significantly increased 7 days after exposure. TiSiO4 NPs significantly increased superoxide dismutase (SOD), glutathione peroxidase (GPx), acetylcholine esterase (AChE), lactate dehydrogenase (LDH) activity, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels in the exposed rat serum, whereas alanine aminotransferase (ALT), aspartate aminotransferase (AST) activity, urea level, immunoglobulins (IgG and IgM) concentrations, progesterone, and testosterone levels were significantly decreased. The liver comet assay indices were significantly increased after 7 days post-exposure. Moreover, histopathological changes and the accumulation of Si and Ti in liver, kidney, spleen, and lung tissues of treated rats were recorded.
Highlights
Nanoscience has grown tremendously with fast‐expanding nanotechnol‐ogy and its broader applications [1]
A sample of the commercial TiSiO4 NPs used in the present study was suspended in deionized water and sonicated for 20 min, and TiSiO4 NPs suspensions were dropped on carbon‐coated copper transmission electron microscopy (TEM) grids and dried prior to measurement
A transmission electron microscopy (TEM) analysis image showed that ≤ 50 nm na‐
Summary
Nanoscience has grown tremendously with fast‐expanding nanotechnol‐ogy and its broader applications [1]. Nanoparticles (NPs) are used in a wide variety of products such as industry, electronics, medicine, and agriculture. They are used as additives for paper packaging, paints, ceramics, foods, drug delivery, biosensors, and cancer therapy [3]. NPs are currently found in over 1000 items or product lines on the market [4]. They have a high surface area to volume ratio in contrast to the larger form of material because the ratio of surface to total atoms or molecules increases exponentially with decreasing particle size, which leads to high surface reactivity, and that affects their physical properties.
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