Abstract
Epigallocatechin-3-gallate (EGCG), an active compound of green tea and its role in diseases cure and prevention has been proven. Its role in diseases management can be attributed to its antioxidant and anti-inflammatory properties. The anti-cancer role of this green tea compound has been confirmed in various types of cancer and is still being under explored. EGCG has been proven to possess a chemopreventive effect through inhibition of carcinogenesis process such as initiation, promotion, and progression. In addition, this catechin has proven its role in cancer management through modulating various cell signaling pathways such as regulating proliferation, apoptosis, angiogenesis and killing of various types of cancer cells. The additive or synergistic effect of epigallocatechin with chemopreventive agents has been verified as it reduces the toxicities and enhances the anti-cancerous effects. Despite its effectiveness and safety, the implications of EGCG in cancer prevention is certainly still discussed due to a poor bioavailability. Several studies have shown the ability to overcome poor bioavailability through nanotechnology-based strategies such as encapsulation, liposome, micelles, nanoparticles and various other formulation. In this review, we encapsulate therapeutic implication of EGCG in cancer management and the mechanisms of action are discussed with an emphasis on human clinical trials.
Highlights
Cancer is a leading public health problem worldwide in term of morbidity and mortality
EGCG is capable of decreasing proliferation and inducing the apoptosis of pancreatic cancer cells linked with the expression of PTEN
The results have revealed that Pro- Epigallocatechin gallate played a role in the inhibition of tumor angiogenesis in xenograft animal models via down-regulation of vascular endothelial growth factor A and HIF-1 α in tumor cells. vascular endothelial growth factors A secretion from endometrial cancer cells was decreased through Pro-Epigallocatechin gallate treatment [61]
Summary
Cancer is a leading public health problem worldwide in term of morbidity and mortality. Many factors are involved in this pathogenesis, including alterations in cell signaling pathways and other various biological process It is a notorious killer disease, and various risk factors linked with cancer seem to be increasing day by day. The exact reasons behind the formation of cancer are still not clear but it is thought that carcinogens are] a major culprit in this notorious disease Chemotherapeutic drugs such as doxorubicin, cisplatin, 5-fluorouracil, and paclitaxel, and radiotherapy are commonly used modes of treatment in most of the cancers. Natural compounds arethea toxicity, good choice in cancer cost of existing anti-cancer drugs, natural compounds are a good choice in cancer management. The same effects as conventional chemotherapeutic drugs with reduced adverse effects [2]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
