Abstract
BackgroundThe outbreak of a new virus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now become the main health concern all over the world. Since effective antiviral treatments have not been developed until now, SARS-CoV-2 is severely affecting countries and territories around the world.MethodsAt the present review, articles in PubMed were searched with the following terms: mesenchymal stem cells, exosomes, coronavirus, and SARS-CoV-2, either alone or in a combination form. The most relevant selected functions were mesenchymal stem cell-derived exosomes and SARS-CoV-2 virus infection.ResultsSARS-CoV-2 could damage pulmonary cells and induce secretion of different types of inflammatory cytokines. In the following, these cytokines trigger inflammation that damages the lungs and results in lethal acute respiratory distress syndrome (ARDS). The main characteristic of ARDS is the onset of inflammation in pulmonary, hyaline formation, pulmonary fibrosis, and edema. Mesenchymal stem cell-derived exosomes (MSC-Exo) are believed to have anti-inflammatory effects and immune-modulating capacity as well as the ability to induce tissue regeneration, suggesting a significant therapeutic opportunity that could be used to SARS-CoV-2 pneumonia treatment. Besides, exosomes may serve as a biomarker, drug delivery system, and vaccine for the management of the patient with SARS-CoV-2.ConclusionMSC-Exo may serve as a promising tool in the treatment of SARS-CoV-2 pneumonia. However, further work needs to be carried out to confirm the efficacy of exosomes in the treatment of SARS-CoV-2 pneumonia.
Highlights
The outbreak of a new virus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become the main health concern all over the world
The exploration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the city of Wuhan in China is done in December 2019
It was demonstrated that mesenchymal stem cells (MSCs) and their derivatives such as exosomes (MSC-Exo) considerably improved lung inflammation and pathological damage resulting from different types of lung injuries [4, 5]
Summary
The outbreak of a new virus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become the main health concern all over the world. Since effective antiviral treatments have not been developed until now, SARS-CoV-2 is severely affecting countries and territories around the world. MSC-Exo have been shown to harbor different proteins and RNAs that have therapeutic effects such as regenerative, anti-inflammatory, pro-angiogenic, immunomodulatory, and anti-fibrotic properties on damaged tissues [6,7,8]. Based on these pieces of evidence, in this review, we aimed to discuss the possible therapeutic application of exosomes in SARS-CoV-2 virus infection
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