Abstract
Isothiocyanates (ITCs), which are organosulfur compounds present in cruciferous vegetables, have anticarcinogenic, antiinflammatory, and antiproliferative activities. These biological activities, and the knowledge that rocket seed (Eruca sativa) extract is used in skin disorders in traditional Middle Eastern medicine, led to the isolation and assessment of 4-methylthiobutylisothiocyanate (MTBI), the major ITC in rocket seeds, for its potential in the prevention of inflammatory skin diseases, such as psoriasis. MTBI was found to depress the growth of activated keratinocytes and to arrest the activated THP-1 monocytes in the G2 stage. Both MTBI and its oxidized derivative sulforaphane (SFN), which was found in the rocket seed at a low concentration, downregulated the expression of the proinflammatory genes, tumor necrosis factor (TNF)-alpha and interleukin (IL)-12/23 p40, as well as that of intercellular adhesion molecule-1, in activated THP-1 cells. These results demonstrate that MTBI may deter the inflammation process, as has been reported for SFN. Furthermore, pretreatment with MTBI hindered the induction of the inflammatory state in the THP-1 cells, as shown by the inhibition of cytokine mRNA expression of IL-1beta, IL-12/23 p40, and TNF-alpha. Overall, our results imply that MTBI may represent a new family of natural compounds possessing significant skin inflammation-preventive activities.
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