Abstract
Tuberculosis is caused by the bacterium Mycobacterium tuberculosis, which by only using a few new antibiotics, can kill the bacteria. Tuberculosis treatment has several stages, namely intensive and advanced stages. Compliance with the use of OAT is an imported factor in the success of TB treatment. The use of many drugs can cause side effects that result in patients stopping treatment when it creates the TB treatment process to fail. Improved adherence can do by using a fixed-dose combination OAT. In the intensive phase, the patient will get a fixed-dose combination containing a mixture of four antibiotics. The purpose of this study is to evaluate the potential side effects that occur during fixed-dose combination OAT treatment at an intensive stage and see the level of compliance of patients taking TB drugs. Observational sampling in TB patients was taking OAT at an acute stage by looking at side effects that arise during treatment and then analyzed using statistics and algorithm Naranjo. The results showed the most common potential side effects for fixed-dose combination OAT in the intensive stage were itching, headache and nausea with a percentage of 72% each, joint pain 45%, stomach pain 36.4%, lack of appetite and rashes 27.3% each and reddish color in the urine 18.2%. The results of the analysis using Naranjo logarithm obtained results eight, which means the side effects might cause due to the use of the drug. The results of patient compliance achieved a 100% compliance rate
Highlights
IntroductionWhere these bacteria are acidresistant and most often attack the lungs even though other organs can attacked as well as bones, brain, kidneys, or lymph nodes [1,2]
Indonesia is one of the countries that have the most TB cases in the world, namely 10% of the pulmonary TB cases that occur in the world
Inclusion criteria included patients diagnosed with TB and received a fixed-dose combination Obat Anti Tuberkulosis (OAT)
Summary
Where these bacteria are acidresistant and most often attack the lungs even though other organs can attacked as well as bones, brain, kidneys, or lymph nodes [1,2]. According to WHO, the success rate of TB treatment is 85%, but Received: December 2019 | Revised: February 2020 | Accepted: February 2020. The success rate of TB treatment in Indonesia is only 81.3%, or below the target of WHO [4]. The potential cause of increased side effects can occur due to consuming drugs regularly, drugs in more than one amount or polypharmacy, or treatment for an extended period, one of which is Tuberculosis
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