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Abstract
Respiratory viral infections in infants and preschool children are often accompanied by repeated episodes of wheezing; which is associated with an increased risk of asthma development. Mechanisms of connection between a viral infection and the subsequent development of allergic inflammation in the respiratory tract are insufficiently studied. Unfortunately; despite the existence of such connection; it is difficult to predict the risk occurrence on the basis of clinical symptoms. Determination of nitrogen oxide in the exhaled air; of the number of eosinophils in the peripheral blood and of bronchoalveolar lavage fluid as well as of IgE was suggested as predictors of allergic inflammation in the airways. But these surrogate markers in patients including children with asthma have a moderate diagnostic accuracy. Their use as a marker of airway eosinophilia can cause a significant amount of false-positive and false-negative results. Recent studies have shown that determination of serum periostin more accurately confirms eosinophilic airway inflammation. The possibility to study this marker in different variants of wheezing in children as a possible predictor of asthma development is discussed based on its reliability; stability and a small variation in determination of eosinophilic inflammation in the airways with symptoms of bronchial obstruction.
Highlights
Respiratory viral infections in infants and preschool children are often accompanied by repeated episodes of wheezing, which is associated with an increased risk of asthma development
Determination of nitrogen oxide in the exhaled air, of the number of eosinophils in the peripheral blood and of bronchoalveolar lavage fluid as well as of IgE was suggested as predictors of allergic inflammation in the airways
These surrogate markers in patients including children with asthma have a moderate diagnostic accuracy. Their use as a marker of airway eosinophilia can cause a significant amount of false-positive and false-negative results
Summary
The possibility to study this marker in different variants of wheezing in children as a possible predictor of asthma development is discussed based on its reliability, stability and a small variation in determination of eosinophilic inflammation in the airways with symptoms of bronchial obstruction. ПЕРИОСТИН КАК ПОТЕНЦИАЛЬНЫЙ МАРКЕР ЭОЗИНОФИЛЬНОГО ВОСПАЛЕНИЯ Одним из таких индикаторов может быть периостин (periostin), роль которого как потенциального маркера эозинофильного воспаления в дыхательных путях и индикатора, определяющего возможность прогнозирования эффективности применения биологических препаратов при бронхиальной астме, в последнее десятилетие активно изучается.
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