Abstract
Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy (RT) are the common cancer treatments. In addition to these limitations, the development of adverse effects from chemotherapy and RT reduces the quality of life for cancer patients. Cellular radiosensitivity, or the ability to resist and overcome cell damage caused by ionizing radiation (IR), is directly related to cancer cells’ response to RT. Therefore, radiobiological research is emphasizing chemical compounds ’radiosensitization of cancer cells so that they are more reactive in the IR spectrum. Recent years researchers have seen an increase in interest in natural products that have antitumor effects with minimal side effects. Natural products, on the other hand, are easy to recover and therefore less expensive. There have been several scientific studies done based on these compounds that have tested their ability in vitro and in vivo to induce tumor radiosensitization. The role of natural products in RT, as well as their usefulness and potential applications, is the goal of this current review.
Highlights
The findings revealed that the number of aberrant crypt foci (ACF)with curcumin is marginally lower at 4 g, which indicates the existence of early pre-invasive lesions may cause curcumin carcinogenicity
It is seen that vitamin D use together with radiotherapy can have a positive effect on cancer treatment [58]
Another study has reported that treatment with Zerumbone suppressed FOXO1 and Akt phosphorylation due to inactivation of IκB kinase α (IKKα) while activating caspase-3 protein and Poly (ADP-ribose) polymerase (PARP), which resulted in decreased cell viability, and induction of apoptosis in glioblastoma multiform (GBM) cells [87]
Summary
Traditional therapeutic therapies can have detrimental effects on the normal tissues too, the main goal of conventional radiation therapy is to give a regulated radiant exposure to a given tumor bulk and to affect carcinoma cells with a high- or low-energy photon beam. The nitro-group reduction reacts with the radicals of IR-DNA in the absence of oxygen, which stabilizes them in accordance with the hypothesis of oxygen fixation This stabilization leads to a breakdown in the DNA spectrum and has effects on target hypoxic cells [8,9]. Combination of RV-effects in the S-process phase in the human breast-cancer line (MCF-7), at 0, 10, 30, and 100 μM concentrations at 1, 2, and 3 Gy dose photon radiations caused cytototoxic symptoms and diminished cell proliferation. High doses of chronic RV were well tolerated and emphasized their function as an additional potential agent for cancer treatment [25]
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