Abstract
Potential Role of Heme Oxygenase-1 in Neuroinflammation Caused By Manganese
Highlights
In humans, excess exposure to manganese (Mn) is associated with a Parkinsonian type neurological disorder
While Mn had minimal effects on its own, induction of HO-1 by LPS was potentiated by Mn
Combined Mn+LPS treatment caused a small, but significant decrease in HO-1. These results indicate that Mn potentiates the induction of HO-1 by LPS in microglia, but not in neuronal cells
Summary
Excess exposure to manganese (Mn) is associated with a Parkinsonian type neurological disorder. While Mn can be directly neurotoxic to neurons (dopaminergic and GABAergic) in the midbrain, it can increase glial (microglia and astrocytes) derived inflammatory products that contribute to the development of Mn neurotoxicity. Several studies report that Mn potentiates the production of inflammatory cytokines, reactive oxygen species, nitric oxide, and prostaglandins induced by inflammagens, such as lipopolysaccharide (LPS) in microglia cells.
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