Abstract
Potential Protective Effects of Rice Seedling Extracts of a Malaysian Rice Variety, Biris, Against Doxorubicin-Induced Cytotoxicity
Highlights
Doxorubicin (DOX) remains one of the most effective anti-cancer drugs against leukaemia, lymphoma and breast cancer (Carvalho et al 2009)
The antioxidant capabilities of rice seedlings extracts (RSE) were evaluated, and the results showed lower amounts of total phenolic content (TPC), but similar total flavonoid content (TFC) and trolox equivalent antioxidant capacity (TEAC), compared to wheatgrass seedlings extracts
The present study investigated the antioxidant properties of the rice seedling extracts (RSE)
Summary
Doxorubicin (DOX) remains one of the most effective anti-cancer drugs against leukaemia, lymphoma and breast cancer (Carvalho et al 2009) It inhibits the activities of human IIA-type topoisomerase by forming a stable complex with DNA, which leads to double-strand breaks and a halt in the cell’s transcriptional activity (Thorn et al 2011). The antioxidant capabilities of many plant extracts are mainly due to the phenolic and flavonoid compounds it contains, as they play important roles in neutralising free radicals, singlet oxygen, and peroxides molecules (Osawa 1994) Another method is to reduce the availability of free Fe3+ in the cell using a metal chelator such as Dexrazoxane, which acts to prevent any iron-based oxygen free-radical damage (Hochster 1998) and is a cardioprotective agent used in clinical settings with proven efficacy (Minotti et al 2004). It may reduce the efficacy of DOX and increase the danger of secondary malignancy in younger cancer patients
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