Abstract
Insecticides and toxicants abound in nature, posing a health risk to humans. Concurrent exposure to many environmental contaminants has been demonstrated to harm myocardial performance and reduce cardiac oxidative stress. The purpose of this research was to study the protective effect of vitamin C (Vit C) on quinalphos (QP)-induced cardiac tissue damage in rats. Eighteen albino male rats were randomly categorised into three groups (n = 6). Control, QP group: rats received distilled water. QP insecticide treatment: an oral administration of QP incorporated in drinking water. QP + Vit C group: rats received QP and Vit C. All the experiments were conducted for ten days. Decline of cardiac antioxidant biomarkers catalase (CAT) and reduced glutathione (GPx) along with increased proinflammatory markers tumour necrosis factor-alpha (TNF-α) and interleukin 6 (IL-6) indicated oxidative and inflammatory damage to the heart following administration of QP when compared to control rats. The light microscopic and ultrastructure appearance of QP-treated cardiomyocytes exhibited cardiac damage. Administration of Vit C showed decreased oxidative and inflammatory biomarkers, confirmed with histological and electron microscopic examination. In conclusion, Vit C protected the heart from QP-induced cardiac damage due to decreased inflammation and oxidative stress.
Highlights
Pesticides have been shown to increase the concentration of reactive oxygen species (ROS), generating oxidative stress as well as a change in the cell’s prooxidant/antioxidant balance [1]
The nuclei were irregular in the majority of atrial myocytes, while some were proOurrecessed, results showed that there is a decrease of the antioxidant enzymes and CAT
Myocytes with broken myofibrils showed isolated areas of myofibril fragand is measured as a biomarker oxidative stress (OxS)
Summary
Pesticides have been shown to increase the concentration of reactive oxygen species (ROS), generating oxidative stress as well as a change in the cell’s prooxidant/antioxidant balance [1]. Pesticide toxicity has been discovered in several research studies and creates oxidative stress in humans and other animals by increasing production of free radicals [2,3,4]. QP is an organophosphate pesticide frequently used in agriculture and the cattle industry. 0.1 per cent of pesticide reaches its intended target, with the rest dissipating in the environment. QP and its metabolites can survive for long periods in water, soil, or plants, posing serious harm to exposed animals and humans [5]. According to recent research, poisoning with QP and its Biomedicines 2022, 10, 39.
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