Abstract
Radiation-induced free radicals in x-ray irradiated L-asparagine have been investigated by Electron Spin Resonance (ESR) spectroscopy, for dosimetric purposes. Optimal signal-to-noise (S/N) ratio and signal intensity for ESR spectra were found for a microwave power of 2 mW, and modulation amplitude of 1 mT. The dosimetric properties of L-asparagine are characterized by a linear dose-response in the therapeutic dose range, and lowest detectable dose was 0.1 Gy, including a small energy dependence (80 KV-6 MV), dose rate independence over a range of clinical relevance (100–600 cGy/min). The ESR signal stability was also investigated in the period of 6 months at room temperature. No changes in the signal intensity were observed over this period. Therefore, we propose L-asparagine as a potential candidate for electron spin resonance dosimetry of ionizing radiation.
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